This discussion between Joe Rogan and Bret Weinstein happened after the major reveal (and full story) on The Portal podcast between Bret and his brother, Eric. I highly recommend listening to it: https://podcasts.apple.com/us/podcast/19-bret-weinstein-the-...
These brothers are smart and often interesting but they are also both audibly quite taken with their own brilliance and often not what I want to listen to.
Lab mice have extremely long telomeres compared to wild mice and humans. This would theoretically make them better able to heal but more prone to cancer. This also makes them a poor model for testing the toxicity of drugs because they would be better able to deal with the damage caused by drug toxicity.
Drugs that have been developed using these mice could have a higher toxicity than the lab mice data suggests. Weinstein uses the Vioxx scandal as a possible example of such a drug.
Agreed. I listened to one of their interviews on Rogan and couldn’t stand it after half an hour. It’s good to be smart but but it seems a bad character trait to be convinced of your own brilliance.
To my ears, Brett talks with the cadence of a man who believes that the thing he's going to say in the following sentence is profound. It might be unintentional on his part, but that's what I hear. Tone and cadence matter in audio formats.
elindbe2 nicely summarizes Bret Weinstein's paper and the Joe Rogan clip.
Eric Weinstein's 2hr+ Portal Podcast #19 on YouTube is frustrating but I'd summarize the "new" info from memory as:
- math oriented older brother Eric thinks biology oriented younger brother Bret is Nobel Prize worthy
- yet Bret and his mouse telomere paper live in obscurity
- reason 1: Bret chose Evergreen rather than a top tier University
- reason 2: the science establishment is biased against disruptive ideas and scientists
- Carol Greider’s 2009 Nobel Prize was based on work inspired by informal phone calls and emails from Bret
- Bret claims that Greider failed to recognize his contribution and then actively undermined his paper(s) through the peer review process
I wish we had TL;DR + Start/Stop Links into the original video. Long form audio/video podcasts are both a boon and a curse since the content cannot easily be searched or linked to.
> Carol Greider’s 2009 Nobel Prize was based on work inspired by informal phone calls and emails from Bret
Bret is quick to point out that Dr. Greider's Nobel prize is well deserved and for related, but earlier work. The contention is over later work.
Their conversation did inspire these findings about lab mice telomeres. But Dr. Greider's lab decided to keep the information "in house". This means that instead of publishing the source of the information, they can use their knowledge to start predicting other results, and publish a full stream of paper first. This is at 1:23:50.
