Not really. I would prefer to keep my profile which has all my history, sessions etc instead of launching a new Firefox every time. Reloading extensions is really not that hard, especially with something like https://chrome.google.com/webstore/detail/extensions-reloade...
I'm sorry, but I seem to not understand how that extension is better than web-ext. web-ext reloads the extension automatically when it changes on disk, "Extensions Reloader" seems to require you to either click a button to reload, or setup your build system to redirect current browser session to "http://reload.extensions", both inferior solutions to just using web-ext.