Sure, you'll get to m6g.16xlarge; but how many companies actually have oltp requirements that exceed the limits of single servers on AWS, eg u-12tb1.112xlarge or u-24tb1.metal (that's 12-24tb memory)? I think these days the issues with high availability, cost/autoscaling/commitment, "tragedy of the commons", bureaucracy, and inter-team boundaries are much more likely to be the drawback than lack of raw power.